[BBLISA] What to do with a RAM-heavy desktop?

[Scott Ehrlich]

So I have a 32 GB, dual quad-core processor desktop to configure.   It 
seems like likely I'd install 32-bit Windows XP on it, with respect to the 
user needing Adobe Acrobat, Illustrator, and Photoshop, along with Matlab 
(which we have Linux versions of) and Mathematica (which we can get Linux 
versions of, too).

But with 32-bit Win XP with SP2, we waste 28 GB, as it can only use 4 GB.

The user is equally Unix-capable, and I could easily install 64-bit 
CentOS, but how could I enable them to fully take advantage of the Adobe 
products on the system natively (i.e w/o using a VM)?

Crossover Office does NOT show the Adobe products as supported apps in 
their tested list.

What to do...

Insights welcome.

Thanks.

Scott